MACHOs: THE PLOT THICKENS

Hemolysis-associated hypercoagulability in sickle cell disease: the plot (and blood) thickens!

Peginterferon maintenance therapy in patients with advanced hepatitis C to prevent hepatocellular carcinoma: the plot thickens.

FV and APC resistance: the plot thickens.

In this issue of Blood, Nogami et al report on a novel factor V (FV) gene mutation (FV Trp1920→Arg, FVNara) associated with activated protein C (APC) resistance and a severe thrombotic phenotype in a young Japanese patient. Since the affected amino acid residue is located in the light chain of FV, far from the known APC-cleavage sites, this discovery may afford new insights into the molecular m...

Keratins and protein synthesis: the plot thickens

In addition to protecting epithelial cells from mechanical stress, keratins regulate cytoarchitecture, cell growth, proliferation, apoptosis, and organelle transport. In this issue, Vijayaraj et al. (2009. J. Cell Biol. doi:10.1083/jcb.200906094) expand our understanding of how keratin proteins participate in the regulation of protein synthesis through their analysis of mice lacking the entire ...

Paul Wellstone : The Plot Thickens

In response to my analysis of the Wellstone tragedy (READER WEEKLY, 28 November 2002, pp. 18-19) and related discussion of this event, I have received quite a few emails, many of which have taken strong exception to the very idea that George W. Bush could ever have been involved in something of this kind. My suggestion that Republicans may have been motivated to take Wellstone out, alas, is not...